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| 1st(1st leg) | Lille OSC | - | AS Monaco | 1:1 | ||
| 2nd (2nd leg) | AS Monaco | - | Lille OSC | 3:2 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 21/03/1978 | Winner: AS Monaco | ||||
| 1st(1st leg) | Stade de Reims | - | SÉC Bastia | 0:1 | ||
| 2nd (2nd leg) | SÉC Bastia | - | Stade de Reims | 2:1 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: SÉC Bastia | ||||
| 1st(1st leg) | Olympique Marseille | - | Girondins Bordeaux | 1:0 | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | Olympique Marseille | 0:2 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: Olympique Marseille | ||||
| 1st(1st leg) | AS Nancy Lorraine | - | FC Martigues | 2:0 | ||
| 2nd (2nd leg) | FC Martigues | - | AS Nancy Lorraine | 1:1 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: AS Nancy Lorraine | ||||
| 1st(1st leg) | FC Nantes | - | USL Dunkerque | 2:0 | ||
| 2nd (2nd leg) | USL Dunkerque | - | FC Nantes | 0:5 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: FC Nantes | ||||
| 1st(1st leg) | FC Metz | - | OGC Nice | 0:2 | ||
| 2nd (2nd leg) | OGC Nice | - | FC Metz | 3:0 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: OGC Nice | ||||
| 1st(1st leg) | AS Angoulême | - | FC Sochaux | 0:0 | ||
| 2nd (2nd leg) | FC Sochaux | - | AS Angoulême | 1:0 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: FC Sochaux | ||||
| 1st(1st leg) | Gazélec FC Ajaccio | - | US Valenciennes-Anzin | 4:1 | ||
| 2nd (2nd leg) | US Valenciennes-Anzin | - | Gazélec FC Ajaccio | 5:0 | ||
| 1st(1st leg): 17/03/1978 | 2nd (2nd leg): 22/03/1978 | Winner: US Valenciennes-Anzin | ||||
