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| 1st(1st leg) | AS Cannes | - | RC Franc-Comtois de Besançon | 1:1 | ||
| 2nd (2nd leg) | RC Franc-Comtois de Besançon | - | AS Cannes | 1:0 | ||
| 1st(1st leg): 07/03/1980 | 2nd (2nd leg): 14/03/1980 | Winner: RC Franc-Comtois de Besançon | ||||
| 1st(1st leg) | Nîmes Olympique | - | FC Sochaux | 1:1 | ||
| 2nd (2nd leg) | FC Sochaux | - | Nîmes Olympique | 1:0 | ||
| 1st(1st leg): 07/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: FC Sochaux | ||||
| 1st(1st leg) | Olympique Avignon-Vaucluse | - | AS Angoulême | 0:0 | ||
| 2nd (2nd leg) | AS Angoulême | - | Olympique Avignon-Vaucluse | 1:0 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: AS Angoulême | ||||
| 1st(1st leg) | AJ Auxerre | - | Calais RUFC | 1:0 | ||
| 2nd (2nd leg) | Calais RUFC | - | AJ Auxerre | 1:5 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 16/03/1980 | Winner: AJ Auxerre | ||||
| 1st(1st leg) | Paris Saint-Germain | - | RC Lens | 0:2 | ||
| 2nd (2nd leg) | RC Lens | - | Paris Saint-Germain | 1:1 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: RC Lens | ||||
| 1st(1st leg) | Lille OSC | - | FC Nantes | 1:0 | ||
| 2nd (2nd leg) | FC Nantes | - | Lille OSC | 1:2 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: Lille OSC | ||||
| 1st(1st leg) | CS Fontainebleau | - | FC Metz | 0:0 | ||
| 2nd (2nd leg) | FC Metz | - | CS Fontainebleau | 2:1 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: FC Metz | ||||
| 1st(1st leg) | FC Martigues | - | AS Monaco | 1:3 | ||
| 2nd (2nd leg) | AS Monaco | - | FC Martigues | 5:2 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: AS Monaco | ||||
| 1st(1st leg) | Montpellier La Paillade SC | - | FC Mulhouse | 4:0 | ||
| 2nd (2nd leg) | FC Mulhouse | - | Montpellier La Paillade SC | 3:2 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: Montpellier La Paillade SC | ||||
| 1st(1st leg) | OGC Nice | - | RC Strasbourg | 2:0 | ||
| 2nd (2nd leg) | RC Strasbourg | - | OGC Nice | 1:0 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: OGC Nice | ||||
| 1st(1st leg) | US Orléans | - | US Montagnarde | 3:0 | ||
| 2nd (2nd leg) | US Montagnarde | - | US Orléans | 0:3 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: US Orléans | ||||
| 1st(1st leg) | Stade Quimpérois | - | Paris FC | 1:2 | ||
| 2nd (2nd leg) | Paris FC | - | Stade Quimpérois | 2:0 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 16/03/1980 | Winner: Paris FC | ||||
| 1st(1st leg) | Stade Rennais | - | Havre AC | 0:0 | ||
| 2nd (2nd leg) | Havre AC | - | Stade Rennais | 2:2 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: Stade Rennais | ||||
| 1st(1st leg) | FC Rouen 1899 | - | AS Saint-Étienne | 0:4 | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | FC Rouen 1899 | 4:2 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | EA Guingamp | - | US Valenciennes-Anzin | 1:2 | ||
| 2nd (2nd leg) | US Valenciennes-Anzin | - | EA Guingamp | 2:0 | ||
| 1st(1st leg): 08/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: US Valenciennes-Anzin | ||||
| 1st(1st leg) | Olympique Alès | - | Stade de Reims | 0:1 | ||
| 2nd (2nd leg) | Stade de Reims | - | Olympique Alès | 4:0 | ||
| 1st(1st leg): 09/03/1980 | 2nd (2nd leg): 15/03/1980 | Winner: Stade de Reims | ||||
