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| 1st(1st leg) | Angers SCO | - | Girondins Bordeaux | 1:4 | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | Angers SCO | 6:0 | ||
| 1st(1st leg): 06/03/1981 | 2nd (2nd leg): 10/03/1981 | Winner: Girondins Bordeaux | ||||
| 1st(1st leg) | Tours FC | - | RC Lens | 1:2 | ||
| 2nd (2nd leg) | RC Lens | - | Tours FC | 2:1 | ||
| 1st(1st leg): 06/03/1981 | 2nd (2nd leg): 10/03/1981 | Winner: RC Lens | ||||
| 1st(1st leg) | AEP Bourg-sous-la-Roche | - | AS Angoulême | 0:1 | ||
| 2nd (2nd leg) | AS Angoulême | - | AEP Bourg-sous-la-Roche | 1:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: AS Angoulême | ||||
| 1st(1st leg) | SÉC Bastia | - | AJ Auxerre | 2:1 | ||
| 2nd (2nd leg) | AJ Auxerre | - | SÉC Bastia | 1:1 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: SÉC Bastia | ||||
| 1st(1st leg) | US Maubeuge | - | LB Châteauroux | 1:3 | ||
| 2nd (2nd leg) | LB Châteauroux | - | US Maubeuge | 5:2 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: LB Châteauroux | ||||
| 1st(1st leg) | AS Poissy | - | Havre AC | 0:0 | ||
| 2nd (2nd leg) | Havre AC | - | AS Poissy | 1:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: Havre AC | ||||
| 1st(1st leg) | Lille OSC | - | CS Thonon-les-Bains | 3:1 | ||
| 2nd (2nd leg) | CS Thonon-les-Bains | - | Lille OSC | 1:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: Lille OSC | ||||
| 1st(1st leg) | USM Malakoff | - | FC Martigues | 1:1 | ||
| 2nd (2nd leg) | FC Martigues | - | USM Malakoff | 0:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: FC Martigues | ||||
| 1st(1st leg) | US Orléans | - | FC Metz | 0:0 | ||
| 2nd (2nd leg) | FC Metz | - | US Orléans | 2:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: FC Metz | ||||
| 1st(1st leg) | Louhans-Cuiseaux | - | Montpellier Paillade SC | 1:2 | ||
| 2nd (2nd leg) | Montpellier Paillade SC | - | Louhans-Cuiseaux | 3:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: Montpellier Paillade SC | ||||
| 1st(1st leg) | Nîmes Olympique | - | AS Nancy Lorraine | 2:4 | ||
| 2nd (2nd leg) | AS Nancy Lorraine | - | Nîmes Olympique | 1:1 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: AS Nancy Lorraine | ||||
| 1st(1st leg) | FC Nantes | - | Paris Saint-Germain | 2:0 | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | FC Nantes | 5:3 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: FC Nantes | ||||
| 1st(1st leg) | FC de Valence | - | AS Saint-Étienne | 0:1 | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | FC de Valence | 5:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | US Fécamp | - | RC Strasbourg | 0:3 | ||
| 2nd (2nd leg) | RC Strasbourg | - | US Fécamp | 4:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: RC Strasbourg | ||||
| 1st(1st leg) | La Sportive Thionvilloise | - | SO Pont-de-Chéruy | 2:0 | ||
| 2nd (2nd leg) | SO Pont-de-Chéruy | - | La Sportive Thionvilloise | 1:3 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: La Sportive Thionvilloise | ||||
| 1st(1st leg) | FC Sochaux | - | AS Monaco | 2:1 | ||
| 2nd (2nd leg) | AS Monaco | - | FC Sochaux | 1:0 | ||
| 1st(1st leg): 07/03/1981 | 2nd (2nd leg): 11/03/1981 | Winner: AS Monaco | ||||
