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| 1st(1st leg) | FC Metz | - | Montpellier Paillade SC | 2:1 | ||
| 2nd (2nd leg) | Montpellier Paillade SC | - | FC Metz | 1:0 | ||
| 1st(1st leg): 02/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: Montpellier Paillade SC | ||||
| 1st(1st leg) | SÉC Bastia | - | AS Monaco | 2:0 | ||
| 2nd (2nd leg) | AS Monaco | - | SÉC Bastia | 2:1 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: SÉC Bastia | ||||
| 1st(1st leg) | FC Nantes | - | Girondins Bordeaux | 1:4 | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | FC Nantes | 6:4 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: Girondins Bordeaux | ||||
| 1st(1st leg) | Havre AC | - | RC Lens | 1:0 | ||
| 2nd (2nd leg) | RC Lens | - | Havre AC | 2:0 aet | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: RC Lens | ||||
| 1st(1st leg) | LB Châteauroux | - | Lille OSC | 1:0 | ||
| 2nd (2nd leg) | Lille OSC | - | LB Châteauroux | 2:0 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: Lille OSC | ||||
| 1st(1st leg) | La Sportive Thionvilloise | - | FC Martigues | 2:2 | ||
| 2nd (2nd leg) | FC Martigues | - | La Sportive Thionvilloise | 3:0 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: FC Martigues | ||||
| 1st(1st leg) | AS Nancy Lorraine | - | AS Saint-Étienne | 2:1 | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | AS Nancy Lorraine | 3:1 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | RC Strasbourg | - | AS Angoulême | 2:0 | ||
| 2nd (2nd leg) | AS Angoulême | - | RC Strasbourg | 2:1 | ||
| 1st(1st leg): 03/04/1981 | 2nd (2nd leg): 11/04/1981 | Winner: RC Strasbourg | ||||
