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| 1st(1st leg) | FC Martigues | - | SC Bastia | 3:0 | ||
| 2nd (2nd leg) | SC Bastia | - | FC Martigues | 5:0 | ||
| 1st(1st leg): 08/05/1981 | 2nd (2nd leg): 19/05/1981 | Winner: SC Bastia | ||||
| 1st(1st leg) | RC Lens | - | Lille OSC | 3:1 | ||
| 2nd (2nd leg) | Lille OSC | - | RC Lens | 1:0 | ||
| 1st(1st leg): 08/05/1981 | 2nd (2nd leg): 19/05/1981 | Winner: RC Lens | ||||
| 1st(1st leg) | AS Saint-Étienne | - | Montpellier La Paillade SC | 2:1 | ||
| 2nd (2nd leg) | Montpellier La Paillade SC | - | AS Saint-Étienne | 1:1 | ||
| 1st(1st leg): 08/05/1981 | 2nd (2nd leg): 19/05/1981 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | Girondins Bordeaux | - | RC Strasbourg | 1:5 | ||
| 2nd (2nd leg) | RC Strasbourg | - | Girondins Bordeaux | 4:0 | ||
| 1st(1st leg): 08/05/1981 | 2nd (2nd leg): 19/05/1981 | Winner: RC Strasbourg | ||||
