1st(1st leg) FC Martigues - SÉC Bastia 3:0
2nd (2nd leg) SÉC Bastia - FC Martigues 5:0
1st(1st leg): 08/05/1981 2nd (2nd leg): 19/05/1981 Winner: SÉC Bastia
1st(1st leg) RC Lens - Lille OSC 3:1
2nd (2nd leg) Lille OSC - RC Lens 1:0
1st(1st leg): 08/05/1981 2nd (2nd leg): 19/05/1981 Winner: RC Lens
1st(1st leg) AS Saint-Étienne - Montpellier Paillade SC 2:1
2nd (2nd leg) Montpellier Paillade SC - AS Saint-Étienne 1:1
1st(1st leg): 08/05/1981 2nd (2nd leg): 19/05/1981 Winner: AS Saint-Étienne
1st(1st leg) Girondins Bordeaux - RC Strasbourg 1:5
2nd (2nd leg) RC Strasbourg - Girondins Bordeaux 4:0
1st(1st leg): 08/05/1981 2nd (2nd leg): 19/05/1981 Winner: RC Strasbourg