1st(1st leg) Sierra Leone - Gambia 0:2 (0:0)
2nd (2nd leg) Gambia - Sierra Leone 1:1 (1:0)
1st(1st leg): 18/10/2021 17:00 2nd (2nd leg): 25/10/2021 17:30 Winner: Gambia
1st(1st leg) Uganda - Ethiopia 2:0 (1:0)
2nd (2nd leg) Ethiopia - Uganda 1:2 (2:0, 2:0) pso
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 26/10/2021 14:00 Winner: Uganda
1st(1st leg) Kenya - South Sudan 8:0 (4:0)
2nd (2nd leg) South Sudan - Kenya 1:7 (0:2)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 23/10/2021 14:00 Winner: Kenya
1st(1st leg) Eritrea - Burundi 0:5
2nd (2nd leg) Burundi - Eritrea 1:0 (1:0)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 26/10/2021 14:00 Winner: Burundi
1st(1st leg) Malawi - Zambia 1:1 (0:1)
2nd (2nd leg) Zambia - Malawi 3:2 (2:1)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 26/10/2021 14:00 Winner: Zambia
1st(1st leg) Tanzania - Namibia 1:2 (1:1)
2nd (2nd leg) Namibia - Tanzania 3:2 (3:1)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 23/10/2021 14:30 Winner: Namibia
1st(1st leg) Zimbabwe - Eswatini 3:1 (3:1)
2nd (2nd leg) Eswatini - Zimbabwe 0:3 (0:1)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 26/10/2021 14:00 Winner: Zimbabwe
1st(1st leg) Mozambique - South Africa 0:7 (0:3)
2nd (2nd leg) South Africa - Mozambique 6:0 (3:0)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 26/10/2021 14:00 Winner: South Africa
1st(1st leg) Central Afr. Republic - Cameroon 0:1 (0:0)
2nd (2nd leg) Cameroon - Central Afr. Republic 2:0 (0:0)
1st(1st leg): 20/10/2021 14:00 2nd (2nd leg): 24/10/2021 15:30 Winner: Cameroon
1st(1st leg) Egypt - Tunisia 2:6 (1:2)
2nd (2nd leg) Tunisia - Egypt 1:0 (0:0)
1st(1st leg): 20/10/2021 15:00 2nd (2nd leg): 26/10/2021 15:00 Winner: Tunisia
1st(1st leg) Congo - Gabon 2:1 (2:0)
2nd (2nd leg) Gabon - Congo 1:0 (0:0)
1st(1st leg): 20/10/2021 15:30 2nd (2nd leg): 26/10/2021 15:30 Winner: Gabon
1st(1st leg) Nigeria - Ghana 2:0 (2:0)
2nd (2nd leg) Ghana - Nigeria 1:0 (0:0)
1st(1st leg): 20/10/2021 16:00 2nd (2nd leg): 24/10/2021 17:00 Winner: Nigeria
1st(1st leg) Niger - Ivory Coast 0:9 (0:5)
2nd (2nd leg) Ivory Coast - Niger 11:0 (5:0)
1st(1st leg): 20/10/2021 16:30 2nd (2nd leg): 25/10/2021 16:30 Winner: Ivory Coast
1st(1st leg) Djibouti - Rwanda 3:0 dec.
2nd (2nd leg) Rwanda - Djibouti 0:3 dec.
1st(1st leg): 20/10/2021 17:00 2nd (2nd leg): 26/10/2021 15:00 Winner: Djibouti
1st(1st leg) Angola - Botswana 1:5 (1:2)
2nd (2nd leg) Botswana - Angola 2:0 (2:0)
1st(1st leg): 20/10/2021 17:00 2nd (2nd leg): 26/10/2021 17:15 Winner: Botswana
1st(1st leg) Liberia - Senegal 1:2 (0:1)
2nd (2nd leg) Senegal - Liberia 6:0 (4:0)
1st(1st leg): 20/10/2021 17:00 2nd (2nd leg): 26/10/2021 18:00 Winner: Senegal
1st(1st leg) Burkina Faso - Benin 2:1 (0:1)
2nd (2nd leg) Benin - Burkina Faso 1:3 (0:1)
1st(1st leg): 20/10/2021 17:00 2nd (2nd leg): 24/10/2021 17:00 Winner: Burkina Faso
1st(1st leg) Mali - Guinea 2:2 (2:1)
2nd (2nd leg) Guinea - Mali 0:2 (0:0)
1st(1st leg): 20/10/2021 17:30 2nd (2nd leg): 25/10/2021 17:00 Winner: Mali
1st(1st leg) Guinea-Bissau - Mauritania 1:0 (0:0)
2nd (2nd leg) Mauritania - Guinea-Bissau 0:1 (0:0)
1st(1st leg): 20/10/2021 17:30 2nd (2nd leg): 26/10/2021 17:00 Winner: Guinea-Bissau
1st(1st leg) Algeria - Sudan 14:0 (9:0)
2nd (2nd leg) Sudan - Algeria resch.
1st(1st leg): 20/10/2021 18:00 2nd (2nd leg): 26/10/2021
1st(1st leg) Equatorial Guinea - Congo DR 3:0 dec.
2nd (2nd leg) Congo DR - Equatorial Guinea 0:3 dec.
1st(1st leg): 20/10/2021 18:00 2nd (2nd leg): 24/10/2021 15:30 Winner: Equatorial Guinea
1st(1st leg) São Tomé and Príncipe - Togo 0:5 (0:2)
2nd (2nd leg) Togo - São Tomé and Príncipe 3:0 dec.
1st(1st leg): 22/10/2021 14:00 2nd (2nd leg): 26/10/2021 17:00 Winner: Togo