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| 28/08/2010 | 13:00 | Terek Grozny | - | Spartak Moskva | 2:0 (0:0) | |
| 13:15 | FK Amkar Perm | - | FK Rostov | 1:0 (1:0) | ||
| 15:30 | FK Saturn | - | Krylia Sovetov | 1:1 (0:0) | ||
| 17:45 | Spartak Nalchik | - | Rubin Kazan | 1:1 (1:1) | ||
| 29/08/2010 | 10:45 | FK Tom Tomsk | - | Dinamo Moskva | 1:0 (0:0) | |
| 13:00 | Lokomotiv Moskva | - | Zenit St. Petersburg | 0:3 (0:1) | ||
| 15:30 | CSKA Moskva | - | Spartak Vladikavkaz | 2:1 (1:0) | ||
| 30/08/2010 | 15:00 | Anzhi Makhachkala | - | Sibir Novosibirsk | 1:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 19 | 13 | 4 | 2 | 30:11 | 19 | 43 |
| 2 |
|
CSKA Moskva | 19 | 12 | 4 | 3 | 33:15 | 18 | 40 |
| 3 |
|
Rubin Kazan | 19 | 10 | 7 | 2 | 21:8 | 13 | 37 |
| 4 |
|
Spartak Nalchik | 19 | 9 | 6 | 4 | 27:20 | 7 | 33 |
| 5 |
|
Spartak Moskva | 19 | 8 | 5 | 6 | 28:24 | 4 | 29 |
| 6 |
|
FK Rostov | 19 | 9 | 2 | 8 | 20:24 | -4 | 29 |
| 7 |
|
Terek Grozny | 19 | 7 | 6 | 6 | 21:16 | 5 | 27 |
| 8 |
|
FK Tom Tomsk | 19 | 7 | 4 | 8 | 25:29 | -4 | 25 |
| 9 |
|
Dinamo Moskva | 19 | 5 | 9 | 5 | 20:18 | 2 | 24 |
| 10 |
|
Lokomotiv Moskva | 19 | 6 | 5 | 8 | 22:24 | -2 | 23 |
| 11 |
|
Anzhi Makhachkala | 19 | 6 | 5 | 8 | 18:21 | -3 | 23 |
| 12 |
|
FK Saturn | 19 | 5 | 6 | 8 | 13:18 | -5 | 21 |
| 13 |
|
Spartak Vladikavkaz | 19 | 5 | 4 | 10 | 17:27 | -10 | 19 |
| 14 |
|
FK Amkar Perm | 19 | 5 | 3 | 11 | 12:20 | -8 | 18 |
| 15 |
|
Krylia Sovetov | 19 | 2 | 7 | 10 | 12:28 | -16 | 13 |
| 16 |
|
Sibir Novosibirsk | 19 | 3 | 3 | 13 | 24:40 | -16 | 12 |
| Champions League | |
| Champions League Quali. | |
| Europa League | |
| Relegation |
