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| 11/12/2021 | 12:00 | FK Radnički 1923 | - | TSC Bačka Topola | 0:3 (0:1) | |
| 14:00 | Radnički Niš | - | FK Čukarički | 1:1 (0:1) | ||
| 16:00 | FK Kolubara | - | Proleter Novi Sad | 2:1 (1:1) | ||
| 13/12/2021 | 17:00 | Crvena Zvezda | - | Radnik Surdulica | 1:1 (1:0) | |
| 14/12/2021 | 12:00 | FK Novi Pazar | - | FK Voždovac | 0:0 (0:0) | |
| 14:00 | Vojvodina | - | Spartak Subotica | 2:3 (0:2) | ||
| 15/12/2021 | 12:00 | Mladost Lučani | - | FK Napredak | 3:2 (2:2) | |
| 14:00 | FK Metalac | - | Partizan | 0:3 (0:3) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 20 | 18 | 2 | 0 | 56:6 | 50 | 56 |
| 2 |
|
Crvena Zvezda | 20 | 16 | 3 | 1 | 47:11 | 36 | 51 |
| 3 |
|
FK Čukarički | 20 | 9 | 8 | 3 | 36:20 | 16 | 35 |
| 4 |
|
Vojvodina | 20 | 8 | 5 | 7 | 28:27 | 1 | 29 |
| 5 |
|
Radnički Niš | 20 | 6 | 9 | 5 | 24:22 | 2 | 27 |
| 6 |
|
FK Napredak | 20 | 8 | 3 | 9 | 25:25 | 0 | 27 |
| 7 |
|
Spartak Subotica | 20 | 7 | 6 | 7 | 24:33 | -9 | 27 |
| 8 |
|
TSC Bačka Topola | 20 | 7 | 5 | 8 | 32:28 | 4 | 26 |
| 9 |
|
FK Voždovac | 20 | 7 | 5 | 8 | 23:24 | -1 | 26 |
| 10 |
|
Proleter Novi Sad | 20 | 7 | 3 | 10 | 16:31 | -15 | 24 |
| 11 |
|
FK Kolubara | 20 | 7 | 2 | 11 | 23:43 | -20 | 23 |
| 12 |
|
Radnik Surdulica | 20 | 4 | 9 | 7 | 16:23 | -7 | 21 |
| 13 |
|
Mladost Lučani | 20 | 6 | 3 | 11 | 22:31 | -9 | 21 |
| 14 |
|
FK Metalac | 20 | 4 | 4 | 12 | 23:36 | -13 | 16 |
| 15 |
|
FK Novi Pazar | 20 | 3 | 7 | 10 | 19:35 | -16 | 16 |
| 16 |
|
FK Radnički 1923 | 20 | 4 | 4 | 12 | 20:39 | -19 | 16 |
| Playoffs | |
| Playoffs |
