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| 15/12/2021 | 16:00 | FK Čukarički | - | FK Radnički 1923 | 2:0 (0:0) | |
| 16/12/2021 | 13:00 | Proleter Novi Sad | - | Radnički Niš | 0:3 dec. | |
| 15:05 | TSC Bačka Topola | - | Crvena Zvezda | 2:3 (2:2) | ||
| 18/12/2021 | 11:55 | Partizan | - | FK Kolubara | 1:0 (0:0) | |
| 12:00 | FK Novi Pazar | - | Vojvodina | 1:1 (0:0) | ||
| 14:00 | FK Napredak | - | Spartak Subotica | 1:0 (0:0) | ||
| 19/12/2021 | 12:00 | Radnik Surdulica | - | Mladost Lučani | 0:2 (0:1) | |
| 14:00 | FK Voždovac | - | FK Metalac | 5:2 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 21 | 19 | 2 | 0 | 57:6 | 51 | 59 |
| 2 |
|
Crvena Zvezda | 21 | 17 | 3 | 1 | 50:13 | 37 | 54 |
| 3 |
|
FK Čukarički | 21 | 10 | 8 | 3 | 38:20 | 18 | 38 |
| 4 |
|
Radnički Niš | 21 | 7 | 9 | 5 | 27:22 | 5 | 30 |
| 5 |
|
Vojvodina | 21 | 8 | 6 | 7 | 29:28 | 1 | 30 |
| 6 |
|
FK Napredak | 21 | 9 | 3 | 9 | 26:25 | 1 | 30 |
| 7 |
|
FK Voždovac | 21 | 8 | 5 | 8 | 28:26 | 2 | 29 |
| 8 |
|
Spartak Subotica | 21 | 7 | 6 | 8 | 24:34 | -10 | 27 |
| 9 |
|
TSC Bačka Topola | 21 | 7 | 5 | 9 | 34:31 | 3 | 26 |
| 10 |
|
Mladost Lučani | 21 | 7 | 3 | 11 | 24:31 | -7 | 24 |
| 11 |
|
Proleter Novi Sad | 21 | 7 | 3 | 11 | 16:34 | -18 | 24 |
| 12 |
|
FK Kolubara | 21 | 7 | 2 | 12 | 23:44 | -21 | 23 |
| 13 |
|
Radnik Surdulica | 21 | 4 | 9 | 8 | 16:25 | -9 | 21 |
| 14 |
|
FK Novi Pazar | 21 | 3 | 8 | 10 | 20:36 | -16 | 17 |
| 15 |
|
FK Metalac | 21 | 4 | 4 | 13 | 25:41 | -16 | 16 |
| 16 |
|
FK Radnički 1923 | 21 | 4 | 4 | 13 | 20:41 | -21 | 16 |
| Playoffs | |
| Playoffs |
