1st(1st leg) 24 Erzincanspor - Hekimoğlu Trabzon 2:0 (0:0)
2nd (2nd leg) Hekimoğlu Trabzon - 24 Erzincanspor 3:0 (2:0)
1st(1st leg): 12/05/2021 14:00 2nd (2nd leg): 16/05/2021 14:00 Winner: Hekimoğlu Trabzon
1st(1st leg) Kırklarelispor - Kırşehir Belediyespor 1:2 (0:1)
2nd (2nd leg) Kırşehir Belediyespor - Kırklarelispor 0:0 (0:0)
1st(1st leg): 12/05/2021 14:00 2nd (2nd leg): 16/05/2021 14:00 Winner: Kırşehir Belediyespor
1st(1st leg) Ankara Demirspor - Kocaelispor 1:1 (0:1)
2nd (2nd leg) Kocaelispor - Ankara Demirspor 3:0 (0:0)
1st(1st leg): 12/05/2021 14:00 2nd (2nd leg): 16/05/2021 18:00 Winner: Kocaelispor
1st(1st leg) Van BBSK - Sakaryaspor 0:2 (0:0)
2nd (2nd leg) Sakaryaspor - Van BBSK 2:0 (1:0)
1st(1st leg): 12/05/2021 14:00 2nd (2nd leg): 16/05/2021 18:00 Winner: Sakaryaspor