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| 1st(1st leg) | 24 Erzincanspor | - | Hekimoğlu Trabzon | 2:0 (0:0) | ||
| 2nd (2nd leg) | Hekimoğlu Trabzon | - | 24 Erzincanspor | 3:0 (2:0) | ||
| 1st(1st leg): 12/05/2021 14:00 | 2nd (2nd leg): 16/05/2021 14:00 | Winner: Hekimoğlu Trabzon | ||||
| 1st(1st leg) | Kırklarelispor | - | Kırşehir Belediyespor | 1:2 (0:1) | ||
| 2nd (2nd leg) | Kırşehir Belediyespor | - | Kırklarelispor | 0:0 (0:0) | ||
| 1st(1st leg): 12/05/2021 14:00 | 2nd (2nd leg): 16/05/2021 14:00 | Winner: Kırşehir Belediyespor | ||||
| 1st(1st leg) | Ankara Demirspor | - | Kocaelispor | 1:1 (0:1) | ||
| 2nd (2nd leg) | Kocaelispor | - | Ankara Demirspor | 3:0 (0:0) | ||
| 1st(1st leg): 12/05/2021 14:00 | 2nd (2nd leg): 16/05/2021 18:00 | Winner: Kocaelispor | ||||
| 1st(1st leg) | Vanspor FK | - | Sakaryaspor | 0:2 (0:0) | ||
| 2nd (2nd leg) | Sakaryaspor | - | Vanspor FK | 2:0 (1:0) | ||
| 1st(1st leg): 12/05/2021 14:00 | 2nd (2nd leg): 16/05/2021 18:00 | Winner: Sakaryaspor | ||||
