| North American SuperLiga | M. | W | D | L | goals | |||
| at home | 1 | 0 | 0 | 1 | 0 | : | 1 | |
| Away | 1 | 1 | 0 | 0 | 2 | : | 1 | |
| ∑ | 2 | 1 | 0 | 1 | 2 | : | 2 | |
| Major League Soccer | M. | W | D | L | goals | |||
| at home | 45 | 24 | 12 | 9 | 85 | : | 50 | |
| Away | 43 | 10 | 10 | 23 | 41 | : | 64 | |
| ∑ | 88 | 34 | 22 | 32 | 126 | : | 114 | |
| U.S. Open Cup | M. | W | D | L | goals | |||
| Away | 2 | 1 | 0 | 1 | 4 | : | 4 | |
| ∑ | 2 | 1 | 0 | 1 | 4 | : | 4 | |
| overall | M. | W | D | L | goals | |||
| at home | 46 | 24 | 12 | 10 | 85 | : | 51 | |
| Away | 46 | 12 | 10 | 24 | 47 | : | 69 | |
| Neutral Place | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 92 | 36 | 22 | 34 | 132 | : | 120 | |
| North American SuperLiga | |||||
| 2010 | Group A | Chicago Fire | - | New England Revolution | 0:1 (0:0) |
| 2009 | Semi-finals | New England Revolution | - | Chicago Fire | 1:2 (1:1) |
| U.S. Open Cup | |||||
| 2025 | Round of 16 | New England Revolution | - | Chicago Fire | 1:3 (0:1) |
| 2016 | Semi-finals | New England Revolution | - | Chicago Fire | 3:1 (2:1) |
|
For games that were decided on penalties the score after 120 minutes will be included in the ranking |
USA 
![Chicago Fire [U18]](https://s.hs-data.com/bilder/wappen/mini/59561.gif?fallback=png "Chicago Fire [U18]"){kind=small}
![Chicago Fire [U17]](https://s.hs-data.com/bilder/wappen/mini/29561.gif?fallback=png "Chicago Fire [U17]"){kind=small}
![Chicago Fire [U16]](https://s.hs-data.com/bilder/wappen/mini/59516.gif?fallback=png "Chicago Fire [U16]"){kind=small}
