Copa Libertadores   M. W D L goals
  at home 2 2 0 0 3 : 0
  Away 2 1 0 1 5 : 4
  4 3 0 1 8 : 4
Copa Sudamericana   M. W D L goals
  at home 2 0 1 1 1 : 2
  Away 2 0 1 1 2 : 4
  4 0 2 2 3 : 6
overall   M. W D L goals
  at home 4 2 1 1 4 : 2
  Away 4 1 1 2 7 : 8
  Neutral Place 0 0 0 0 0 : 0
  8 3 2 3 11 : 10
Copa Libertadores
1997 Group 5 Peñarol - Deportivo Cali 4:3 (1:2)
1997 Group 5 Deportivo Cali - Peñarol 2:0 (0:0)
1978 Group 4 Peñarol - Deportivo Cali 0:2 (0:1)
1978 Group 4 Deportivo Cali - Peñarol 1:0 (1:0)
Copa Sudamericana
2019 2. Round Peñarol - Deportivo Cali 2:0 (0:0)
2019 2. Round Deportivo Cali - Peñarol 1:1 (0:0)
2014 2. Round Deportivo Cali - Peñarol 0:1 (0:1)
2014 2. Round Peñarol - Deportivo Cali 2:2 (0:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking