Copa Libertadores   M. W D L goals
  at home 4 3 1 0 10 : 2
  Away 4 3 1 0 7 : 2
  8 6 2 0 17 : 4
overall   M. W D L goals
  at home 4 3 1 0 10 : 2
  Away 4 3 1 0 7 : 2
  Neutral Place 0 0 0 0 0 : 0
  8 6 2 0 17 : 4
Copa Libertadores
2017 Round of 16 River Plate - Guaraní 1:1 (0:1)
2017 Round of 16 Guaraní - River Plate 0:2 (0:1)
2015 Semi-finals Guaraní - River Plate 1:1 (0:0)
2015 Semi-finals River Plate - Guaraní 2:0 (0:0)
2001 Group 5 Guaraní - River Plate 0:1 (0:1)
2001 Group 5 River Plate - Guaraní 4:0 (1:0)
1966 Group A River Plate - Guaraní 3:1 (1:0)
1966 Group A Guaraní - River Plate 1:3 (0:2)

For games that were decided on penalties the score after 120 minutes will be included in the ranking