1. Round
13/10/2021 20:00 Sinop - MT - Porto Velho EC - RO 0:1 (0:0)
20:00 Fast Clube - AM - Castanhal - PA 0:2 (0:2)
20:00 Águia Negra - MS - Nova Mutum - MT 1:3 (0:1)
20:00 Brasiliense - DF - Rio Branco - ES 5:3 (0:0, 0:0) pso
20:30 Real Ariquemes - RO - Penarol - AM 0:2 (0:2)
21:00 Galvez - AC - Ypiranga - AP 4:1 (0:0, 1:1) pso
14/10/2021 19:00 Gama - DF - Aquidauanense - MS 0:1 (0:0)
20:00 Interporto - TO - Rio Branco VN - ES 0:1 (0:1)
Round of 16
20/10/2021 00:30 Remo - PA - Galvez - AC 9:0 (3:0)
20:00 Manaus - AM - Porto Velho EC - RO 2:0 (0:0)
21:00 São Raimundo - RR - Castanhal - PA 1:2 (1:2)
22:00 Rio Branco - AC - Nova Mutum - MT 1:4 (0:3)
21/10/2021 00:00 Paysandu - PA - Penarol - AM 6:0 (4:0)
01:00 Cuiabá - MT - Brasiliense - DF 6:7 (0:0, 0:0, 0:0) pso
22:00 Atlético Acreano - AC - Aquidauanense - MS 4:5 (1:1, 1:1) pso
23:30 Vila Nova - GO - Rio Branco VN - ES 3:0 (2:0)
Quarter-finals
28/10/2021 00:00 Paysandu - PA - Castanhal - PA 1:1 (1:0)
19:00 Brasiliense - DF - Nova Mutum - MT 1:0 (0:0)
20:00 Aquidauanense - MS - Vila Nova - GO 0:1 (0:1)
12/11/2021 20:30 Manaus - AM - Remo - PA 1:1 (0:0)
03/11/2021 19:00 Nova Mutum - MT - Brasiliense - DF 3:2 (0:0, 0:0, 0:0) pso
04/11/2021 22:30 Vila Nova - GO - Aquidauanense - MS 7:0 (2:0)
10/11/2021 22:30 Castanhal - PA - Paysandu - PA 1:3 (1:1)
24/11/2021 23:30 Remo - PA - Manaus - AM 3:0 (2:0)
Semi-finals
24/11/2021 22:30 Vila Nova - GO - Nova Mutum - MT 3:0 (0:0)
01/12/2021 23:00 Paysandu - PA - Remo - PA 2:2 (2:0)
02/12/2021 19:00 Nova Mutum - MT - Vila Nova - GO 1:1 (0:0)
04/12/2021 20:00 Remo - PA - Paysandu - PA 2:0 (1:0)
Final
08/12/2021 23:00 Vila Nova - GO - Remo - PA 0:0 (0:0)
11/12/2021 20:00 Remo - PA - Vila Nova - GO 4:2 (0:0, 0:0, 0:0) pso