| 1. Round | 17/07/2021 | Lanús | - | Atlético Tucumán | 4:2 |  |
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| 11. Round | 14/09/2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | |
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| 12. Round | 19/09/2021 | Atlético Tucumán | - | Boca Juniors | 1:2 | ||||
| 14. Round | 02/10/2021 | Atlético Tucumán | - | San Lorenzo | 0:0 | ||||
| 17. Round | 20/10/2021 | Estudiantes | - | Atlético Tucumán | 1:1 | ||||
| 18. Round | 25/10/2021 | Atlético Tucumán | - | Patronato de Paraná | 2:2 | ||||
| 20. Round | 06/11/2021 | Atlético Tucumán | - | Racing Club | 0:2 | |
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| 22. Round | 24/11/2021 | Atlético Tucumán | - | Defensa y Justicia | 0:4 | |
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| 23. Round | 29/11/2021 | Unión de Santa Fe | - | Atlético Tucumán | 3:0 | |
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| 24. Round | 03/12/2021 | Colón de Santa Fe | - | Atlético Tucumán | 3:0 | ||||
| 25. Round | 11/12/2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentina