| 1. Round | 01/12/2021 | CFI Alicante | - | Real Betis | 0:4 | ||||
| 2. Round | 16/12/2021 | CF Talavera | - | Real Betis | 2:4 aet | ||||
| 3. Round | 05/01/2022 | Real Valladolid | - | Real Betis | 0:3 | ||||
| Quarter-finals | 03/02/2022 | Real Sociedad | - | Real Betis | 0:4 |  |
|||
| Semi-finals | 09/02/2022 | Rayo Vallecano | - | Real Betis | 1:2 | ||||
| Final | 23/04/2022 | Real Betis | - | Valencia CF | 5:4 pso |
Spain