| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 |  |
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| 3. Round | 28/07/2021 | Boca Juniors | - | San Lorenzo | 0:2 | ||||
| 4. Round | 02/08/2021 | San Lorenzo | - | Banfield | 1:1 | ||||
| 5. Round | 07/08/2021 | Unión de Santa Fe | - | San Lorenzo | 4:0 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 11. Round | 13/09/2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 17. Round | 20/10/2021 | San Lorenzo | - | Lanús | 1:3 | ||||
| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
| 19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 21. Round | 19/11/2021 | San Lorenzo | - | Gimnasia de La Plata | 0:1 |
Argentina