| 1. Round | 13/08/2021 | KMSK Deinze | - | Lierse Kempenzonen | 1:1 | ||||
| 2. Round | 22/08/2021 | Lierse Kempenzonen | - | Excelsior Virton | 2:0 | ||||
| 3. Round | 28/08/2021 | KVC Westerlo | - | Lierse Kempenzonen | 3:2 |  |
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| 4. Round | 12/09/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 4:1 | |
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| 5. Round | 19/09/2021 | Lommel SK | - | Lierse Kempenzonen | 3:1 | ||||
| 6. Round | 24/09/2021 | Lierse Kempenzonen | - | Waasland-Beveren | 2:1 |  |
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| 7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 8. Round | 16/10/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:1 | ||||
| 9. Round | 23/10/2021 | Lierse Kempenzonen | - | KMSK Deinze | 2:2 | |
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| 11. Round | 07/11/2021 | RWD Molenbeek | - | Lierse Kempenzonen | 3:3 | ||||
| 12. Round | 20/11/2021 | Lierse Kempenzonen | - | KVC Westerlo | 1:5 | |
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| 13. Round | 28/11/2021 | Royal Excel Mouscron | - | Lierse Kempenzonen | 2:1 | ||||
| 14. Round | 05/12/2021 | Lierse Kempenzonen | - | Lommel SK | 2:2 | |
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| 15. Round | 12/12/2021 | Excelsior Virton | - | Lierse Kempenzonen | 2:2 | ||||
| 16. Round | 19/12/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 0:1 |
Belgium