| 1. Round | 11/01/2022 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 1:4 |  |
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| 4. Round | 28/01/2022 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:3 | |
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| 5. Round | 01/02/2022 | Deportivo Guadalajara [Women] | - | Cruz Azul [Women] | 1:0 | |
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| 6. Round | 04/02/2022 | Gallos Blancos [Women] | - | Deportivo Guadalajara [Women] | 2:2 | |
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| 7. Round | 13/02/2022 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | |
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| 10. Round | 14/03/2022 | CF América [Women] | - | Deportivo Guadalajara [Women] | 1:2 | |
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| 11. Round | 18/03/2022 | Deportivo Guadalajara [Women] | - | Club Tijuana [Women] | 3:0 | ||||
| 12. Round | 22/03/2022 | Deportivo Guadalajara [Women] | - | Puebla FC [Women] | 1:0 | |
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| 13. Round | 29/03/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:2 | |
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| 14. Round | 04/04/2022 | Mazatlán FC [Women] | - | Deportivo Guadalajara [Women] | 0:1 | |
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| 15. Round | 18/04/2022 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 2:1 | |
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| 16. Round | 23/04/2022 | Atlas Guadalajara [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 17. Round | 03/05/2022 | Deportivo Guadalajara [Women] | - | CF Monterrey [Women] | 1:0 |
Mexico