| 1. Round | 12/01/2021 | Deportivo Guadalajara [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 2. Round | 16/01/2021 | Mazatlán FC [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 3. Round | 25/01/2021 | Deportivo Guadalajara [Women] | - | Santos Laguna [Women] | 2:0 | ||||
| 8. Round | 28/02/2021 | Deportivo Guadalajara [Women] | - | Club León [Women] | 5:1 | ||||
| 9. Round | 09/03/2021 | Club Tijuana [Women] | - | Deportivo Guadalajara [Women] | 2:1 | ||||
| 11. Round | 14/03/2021 | Atlas Guadalajara [Women] | - | Deportivo Guadalajara [Women] | 3:3 | ||||
| 13. Round | 28/03/2021 | CF América [Women] | - | Deportivo Guadalajara [Women] | 2:4 | ||||
| 14. Round | 03/04/2021 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 4:1 | ||||
| 16. Round | 26/04/2021 | Deportivo Guadalajara [Women] | - | CF Monterrey [Women] | 5:0 | ||||
| 17. Round | 04/05/2021 | Deportivo Guadalajara [Women] | - | UANL Tigres [Women] | 3:4 |
Mexico