| 3. Round | 26/01/2021 | UANL Tigres [Women] | - | Puebla FC [Women] | 2:1 |  |
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| 4. Round | 02/02/2021 | Santos Laguna [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 7. Round | 15/02/2021 | Club León [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 8. Round | 02/03/2021 | UANL Tigres [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 9. Round | 06/03/2021 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:4 | |
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| 11. Round | 16/03/2021 | CF América [Women] | - | UANL Tigres [Women] | 2:2 | ||||
| 12. Round | 23/03/2021 | UANL Tigres [Women] | - | FC Juárez [Women] | 3:0 | ||||
| 13. Round | 30/03/2021 | CF Monterrey [Women] | - | UANL Tigres [Women] | 2:2 | ||||
| 14. Round | 06/04/2021 | UANL Tigres [Women] | - | Cruz Azul [Women] | 3:0 | |
Mexico