| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 2. Round | 14/08/2021 | FC Martigues | - | Olympique Lyonnais B | 1:1 |  |
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| 3. Round | 21/08/2021 | Olympique Lyonnais B | - | GFA Rumilly Vallières | 0:2 | ||||
| 4. Round | 28/08/2021 | AS Saint-Priest | - | Olympique Lyonnais B | 1:3 | |
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| 5. Round | 04/09/2021 | Olympique Lyonnais B | - | Étoile FC | 3:0 | |
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| 6. Round | 11/09/2021 | GOAL FC | - | Olympique Lyonnais B | 2:0 | ||||
| 8. Round | 25/09/2021 | Jura Sud | - | Olympique Lyonnais B | 1:1 | ||||
| 9. Round | 09/10/2021 | Olympique Lyonnais B | - | Olympique Marseille B | 2:2 |  |
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| 10. Round | 23/10/2021 | Marignane Gignac FC | - | Olympique Lyonnais B | 4:0 | ||||
| 14. Round | 11/12/2021 | Olympique Lyonnais B | - | Hyères FC | 3:2 | ||||
| 13. Round | 18/12/2021 | Louhans-Cuiseaux | - | Olympique Lyonnais B | 1:2 | ||||
| 16. Round | 22/01/2022 | Olympique Lyonnais B | - | FC Martigues | 0:1 | ||||
| 15. Round | 26/01/2022 | Lyon-La Duchère | - | Olympique Lyonnais B | 0:0 | ||||
| 20. Round | 05/03/2022 | Olympique Lyonnais B | - | GOAL FC | 0:2 | ||||
| 22. Round | 19/03/2022 | Olympique Lyonnais B | - | Jura Sud | 0:4 |
France
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