| 1. Round | 12/02/2022 | Almagro | - | Mitre de SdE | 2:1 | ||||
| 2. Round | 19/02/2022 | Sacachispas | - | Almagro | 0:1 | ||||
| 3. Round | 28/02/2022 | Almagro | - | Instituto de Córdoba | 0:1 | ||||
| 4. Round | 05/03/2022 | Agropecuario Argentino | - | Almagro | 2:2 |  |
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| 5. Round | 11/03/2022 | Almagro | - | Tristan Suárez | 1:0 | ||||
| 8. Round | 28/03/2022 | Brown de Adrogué | - | Almagro | 3:0 | ||||
| 10. Round | 10/04/2022 | Guillermo Brown | - | Almagro | 0:1 | ||||
| 11. Round | 17/04/2022 | Almagro | - | Atlético Rafaela | 3:1 | |
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| 12. Round | 23/04/2022 | Ramón Santamarina | - | Almagro | 0:0 | ||||
| 13. Round | 30/04/2022 | Almagro | - | Estudiantes de Caseros | 1:1 | ||||
| 14. Round | 07/05/2022 | Atlanta | - | Almagro | 1:1 | ||||
| 15. Round | 14/05/2022 | Almagro | - | San Martín de San Juan | 1:0 | ||||
| 16. Round | 24/05/2022 | Chaco For Ever | - | Almagro | 0:1 | ||||
| 17. Round | 30/05/2022 | Almagro | - | San Telmo | 2:1 | ||||
| 18. Round | 05/06/2022 | Gimnasia de Mendoza | - | Almagro | 1:0 | |
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| 23. Round | 09/07/2022 | Almagro | - | Villa Dálmine | 1:0 | ||||
| 34. Round | 18/09/2022 | Almagro | - | Deportivo Maipú | 1:0 |
Argentina