| 1. Round | 18/07/2021 | Arsenal de Sarandí | - | San Lorenzo | 1:1 | ||||
| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 | ||||
| 6. Round | 16/08/2021 | Talleres de Córdoba | - | San Lorenzo | 2:0 | ||||
| 7. Round | 22/08/2021 | San Lorenzo | - | Argentinos Juniors | 0:1 | ||||
| 8. Round | 26/08/2021 | Estudiantes | - | San Lorenzo | 2:0 | ||||
| 11. Round | 13/09/2021 | San Lorenzo | - | Racing Club | 1:1 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
| 25. Round | 12/12/2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
Argentina