| 3. Round | 27/07/2021 | Huracán | - | Colón de Santa Fe | 1:1 | ||||
| 4. Round | 01/08/2021 | River Plate | - | Huracán | 1:1 |  |
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| 7. Round | 21/08/2021 | Godoy Cruz | - | Huracán | 1:1 | ||||
| 10. Round | 04/09/2021 | Huracán | - | Aldosivi | 2:0 | ||||
| 11. Round | 13/09/2021 | Sarmiento de Junín | - | Huracán | 0:0 |  |
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| 13. Round | 28/09/2021 | Newell's Old Boys | - | Huracán | 0:1 | |
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| 14. Round | 02/10/2021 | Huracán | - | Arsenal de Sarandí | 1:0 | |
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| 15. Round | 08/10/2021 | Central Córdoba SdE | - | Huracán | 1:2 |  |
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| 16. Round | 17/10/2021 | Huracán | - | Boca Juniors | 0:3 | |
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| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
| 19. Round | 30/10/2021 | Talleres de Córdoba | - | Huracán | 1:0 | |
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| 20. Round | 08/11/2021 | Huracán | - | Argentinos Juniors | 1:1 | |
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| 21. Round | 19/11/2021 | Estudiantes | - | Huracán | 4:1 | ||||
| 22. Round | 23/11/2021 | Huracán | - | Patronato de Paraná | 1:0 | ||||
| 23. Round | 30/11/2021 | Platense | - | Huracán | 4:2 | ||||
| 24. Round | 05/12/2021 | Huracán | - | Racing Club | 1:0 | ||||
| 25. Round | 11/12/2021 | Rosario Central | - | Huracán | 1:4 |
Argentina