| 1. Round | 16/08/2021 | Crystal Palace U23 | - | Leeds United U23 | 1:3 |  |
|||
| 2. Round | 23/08/2021 | Leeds United U23 | - | Tottenham Hotspur U23 | 2:4 | ||||
| 3. Round | 27/08/2021 | Derby County U23 | - | Leeds United U23 | 2:3 | ||||
| 4. Round | 11/09/2021 | Leeds United U23 | - | West Ham United U23 | 2:2 | ||||
| 5. Round | 19/09/2021 | Liverpool FC U23 | - | Leeds United U23 | 0:4 | ||||
| 8. Round | 18/10/2021 | Everton FC U23 | - | Leeds United U23 | 4:2 | |
|||
| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 13. Round | 29/11/2021 | Manchester City U23 | - | Leeds United U23 | 3:2 | ||||
| 14. Round | 03/12/2021 | Leeds United U23 | - | Leicester City U23 | 1:3 |  |
|||
| 19. Round | 07/02/2022 | Leeds United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 22. Round | 15/03/2022 | Leeds United U23 | - | Manchester United U23 | 3:0 | ||||
| 24. Round | 04/04/2022 | Leeds United U23 | - | Crystal Palace U23 | 4:0 | ||||
| 20. Round | 15/04/2022 | Brighton & Hove Albion U23 | - | Leeds United U23 | 1:0 | ||||
| 25. Round | 22/04/2022 | Leeds United U23 | - | Manchester City U23 | 1:3 |
England