| 1. Round | 08/01/2022 | Pumas UNAM [Women] | - | Club León [Women] | 1:0 | ||||
| 2. Round | 18/01/2022 | Club León [Women] | - | FC Juárez [Women] | 1:3 | ||||
| 3. Round | 25/01/2022 | CF Pachuca [Women] | - | Club León [Women] | 3:0 | ||||
| 4. Round | 28/01/2022 | Club León [Women] | - | Club Tijuana [Women] | 1:1 |  |
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| 5. Round | 01/02/2022 | Club León [Women] | - | Gallos Blancos [Women] | 4:2 | ||||
| 6. Round | 08/02/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:3 | ||||
| 7. Round | 11/02/2022 | Club León [Women] | - | CF América [Women] | 1:4 | ||||
| 8. Round | 01/03/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:0 | |
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| 10. Round | 13/03/2022 | Mazatlán FC [Women] | - | Club León [Women] | 0:0 | ||||
| 11. Round | 17/03/2022 | Club León [Women] | - | Puebla FC [Women] | 2:0 | |
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| 12. Round | 22/03/2022 | UANL Tigres [Women] | - | Club León [Women] | 6:0 | ||||
| 13. Round | 29/03/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:2 | |
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| 9. Round | 11/04/2022 | Club León [Women] | - | CF Monterrey [Women] | 1:6 | |
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| 16. Round | 26/04/2022 | Club León [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
| 17. Round | 02/05/2022 | Atlas Guadalajara [Women] | - | Club León [Women] | 2:1 | |
Mexico