| 1. Round | 08/01/2022 | Mazatlán FC [Women] | - | Cruz Azul [Women] | 1:2 |  |
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| 2. Round | 18/01/2022 | Atlético San Luis [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 3. Round | 22/01/2022 | Cruz Azul [Women] | - | Gallos Blancos [Women] | 0:1 | ||||
| 6. Round | 05/02/2022 | Cruz Azul [Women] | - | CF América [Women] | 1:3 | |
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| 7. Round | 12/02/2022 | Pumas UNAM [Women] | - | Cruz Azul [Women] | 1:1 | |
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| 8. Round | 26/02/2022 | Cruz Azul [Women] | - | Club Tijuana [Women] | 2:2 | ||||
| 10. Round | 12/03/2022 | Cruz Azul [Women] | - | Santos Laguna [Women] | 2:3 | ||||
| 11. Round | 18/03/2022 | UANL Tigres [Women] | - | Cruz Azul [Women] | 4:0 | ||||
| 12. Round | 21/03/2022 | Cruz Azul [Women] | - | CF Pachuca [Women] | 0:2 | ||||
| 13. Round | 26/03/2022 | Cruz Azul [Women] | - | Atlas Guadalajara [Women] | 2:1 | |
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| 14. Round | 01/04/2022 | Club León [Women] | - | Cruz Azul [Women] | 2:3 | ||||
| 9. Round | 11/04/2022 | Deportivo Toluca [Women] | - | Cruz Azul [Women] | 3:1 | ||||
| 15. Round | 16/04/2022 | Cruz Azul [Women] | - | CF Monterrey [Women] | 1:3 | ||||
| 16. Round | 22/04/2022 | Club Necaxa [Women] | - | Cruz Azul [Women] | 1:2 | ||||
| 17. Round | 30/04/2022 | Cruz Azul [Women] | - | Puebla FC [Women] | 3:1 |
Mexico