| 8. Round | 13/07/2022 | San Lorenzo II | - | Banfield II | 0:1 | ||||
| 9. Round | 19/07/2022 | Unión de Santa Fe II | - | San Lorenzo II | 0:0 | ||||
| 10. Round | 24/07/2022 | Talleres de Córdoba II | - | San Lorenzo II | 1:3 | ||||
| 11. Round | 01/08/2022 | San Lorenzo II | - | Argentinos Juniors II | 3:4 | ||||
| 12. Round | 08/08/2022 | Estudiantes II | - | San Lorenzo II | 4:2 |  |
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| 13. Round | 12/08/2022 | San Lorenzo II | - | Patronato de Paraná II | 1:2 | ||||
| 16. Round | 28/08/2022 | Rosario Central II | - | San Lorenzo II | 0:1 | ||||
| 17. Round | 01/09/2022 | San Lorenzo II | - | Defensa y Justicia II | 1:0 | ||||
| 19. Round | 12/09/2022 | San Lorenzo II | - | Colón de Santa Fe II | 2:1 | ||||
| 21. Round | 25/09/2022 | San Lorenzo II | - | Lanús II | 1:2 | ||||
| 23. Round | 04/10/2022 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 24. Round | 10/10/2022 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 25. Round | 14/10/2022 | San Lorenzo II | - | Gimnasia de La Plata II | 3:1 | ||||
| 26. Round | 18/10/2022 | San Lorenzo II | - | Sarmiento de Junín II | 0:0 | ||||
| 27. Round | 23/10/2022 | Aldosivi II | - | San Lorenzo II | 2:3 |
Argentina