| 1. Round | 06/06/2022 | Defensa y Justicia | - | River Plate | 0:0 | ||||
| 2. Round | 12/06/2022 | River Plate | - | Atlético Tucumán | 0:0 | ||||
| 3. Round | 15/06/2022 | Colón de Santa Fe | - | River Plate | 1:0 | ||||
| 4. Round | 19/06/2022 | Unión de Santa Fe | - | River Plate | 1:5 | ||||
| 5. Round | 26/06/2022 | River Plate | - | Lanús | 2:1 | ||||
| 6. Round | 04/07/2022 | Huracán | - | River Plate | 3:2 | ||||
| 8. Round | 18/07/2022 | Vélez Sarsfield | - | River Plate | 2:2 |  |
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| 9. Round | 22/07/2022 | River Plate | - | Gimnasia de La Plata | 1:0 | ||||
| 10. Round | 24/07/2022 | Aldosivi | - | River Plate | 0:3 | ||||
| 11. Round | 01/08/2022 | River Plate | - | Sarmiento de Junín | 1:2 | ||||
| 12. Round | 07/08/2022 | Independiente | - | River Plate | 0:1 | ||||
| 13. Round | 14/08/2022 | River Plate | - | Newell's Old Boys | 4:1 | ||||
| 15. Round | 21/08/2022 | River Plate | - | Central Córdoba SdE | 3:0 | ||||
| 17. Round | 05/09/2022 | River Plate | - | Barracas Central | 2:0 | ||||
| 19. Round | 14/09/2022 | River Plate | - | Banfield | 1:2 | ||||
| 26. Round | 17/10/2022 | River Plate | - | Rosario Central | 1:2 |
Argentina