| 1. Round | 12/01/2021 | UANL Tigres [Women] | - | CF Pachuca [Women] | 3:0 | ||||
| 2. Round | 18/01/2021 | CF Pachuca [Women] | - | Santos Laguna [Women] | 1:2 | ||||
| 3. Round | 23/01/2021 | FC Juárez [Women] | - | CF Pachuca [Women] | 1:1 | ||||
| 4. Round | 01/02/2021 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 1:0 | ||||
| 5. Round | 04/02/2021 | Atlas Guadalajara [Women] | - | CF Pachuca [Women] | 3:3 |  |
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| 6. Round | 09/02/2021 | CF Pachuca [Women] | - | Deportivo Toluca [Women] | 2:0 | |
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| 7. Round | 13/02/2021 | Pumas UNAM [Women] | - | CF Pachuca [Women] | 1:0 | ||||
| 8. Round | 02/03/2021 | CF Pachuca [Women] | - | CF Monterrey [Women] | 1:0 | |
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| 9. Round | 04/03/2021 | Gallos Blancos [Women] | - | CF Pachuca [Women] | 0:3 | |
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| 10. Round | 10/03/2021 | Cruz Azul [Women] | - | CF Pachuca [Women] | 2:1 | ||||
| 14. Round | 06/04/2021 | CF Pachuca [Women] | - | Club Tijuana [Women] | 2:1 | |
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| 15. Round | 17/04/2021 | Mazatlán FC [Women] | - | CF Pachuca [Women] | 0:2 | ||||
| 16. Round | 23/04/2021 | Club Necaxa [Women] | - | CF Pachuca [Women] | 1:0 | ||||
| 17. Round | 01/05/2021 | CF Pachuca [Women] | - | Atlético San Luis [Women] | 4:1 | |
Mexico