| 4. Round | 19/06/2022 | Huracán | - | Atlético Tucumán | 0:0 | ||||
| 5. Round | 28/06/2022 | Atlético Tucumán | - | Godoy Cruz | 1:1 | ||||
| 7. Round | 10/07/2022 | Atlético Tucumán | - | Gimnasia de La Plata | 2:0 | ||||
| 11. Round | 31/07/2022 | Atlético Tucumán | - | Newell's Old Boys | 2:0 | ||||
| 12. Round | 06/08/2022 | Arsenal de Sarandí | - | Atlético Tucumán | 3:1 | ||||
| 15. Round | 24/08/2022 | Atlético Tucumán | - | Barracas Central | 4:0 | ||||
| 17. Round | 06/09/2022 | Atlético Tucumán | - | Banfield | 0:0 | ||||
| 18. Round | 10/09/2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 19. Round | 16/09/2022 | Atlético Tucumán | - | Talleres de Córdoba | 1:1 | ||||
| 20. Round | 20/09/2022 | Argentinos Juniors | - | Atlético Tucumán | 1:2 | ||||
| 22. Round | 02/10/2022 | Patronato de Paraná | - | Atlético Tucumán | 2:1 | ||||
| 23. Round | 05/10/2022 | Atlético Tucumán | - | Platense | 2:1 | ||||
| 24. Round | 10/10/2022 | Racing Club | - | Atlético Tucumán | 2:0 | ||||
| 25. Round | 14/10/2022 | Atlético Tucumán | - | Rosario Central | 1:1 | ||||
| 26. Round | 18/10/2022 | Atlético Tucumán | - | Unión de Santa Fe | 1:1 |  |
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| 27. Round | 22/10/2022 | Defensa y Justicia | - | Atlético Tucumán | 3:1 |
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