| 1. Round | 17/07/2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Round | 27/07/2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Round | 30/07/2021 | Newell's Old Boys | - | Estudiantes | 4:2 | ||||
| 4. Round | 02/08/2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 | ||||
| 5. Round | 07/08/2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 6. Round | 16/08/2021 | Racing Club | - | Newell's Old Boys | 2:0 |  |
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| 7. Round | 22/08/2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Round | 25/08/2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Round | 04/09/2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 |  |
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| 11. Round | 16/09/2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Round | 20/09/2021 | Lanús | - | Newell's Old Boys | 1:2 | ||||
| 18. Round | 25/10/2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | |
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| 22. Round | 24/11/2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 |
Argentina