| 4. Round | 21/06/2022 | Newell's Old Boys | - | Argentinos Juniors | 1:0 | ||||
| 5. Round | 25/06/2022 | Estudiantes | - | Newell's Old Boys | 0:2 | ||||
| 6. Round | 04/07/2022 | Newell's Old Boys | - | Patronato de Paraná | 2:2 | ||||
| 7. Round | 10/07/2022 | Platense | - | Newell's Old Boys | 1:1 | ||||
| 8. Round | 16/07/2022 | Newell's Old Boys | - | Racing Club | 0:0 |  |
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| 12. Round | 08/08/2022 | Newell's Old Boys | - | Colón de Santa Fe | 0:0 | ||||
| 13. Round | 14/08/2022 | River Plate | - | Newell's Old Boys | 4:1 | ||||
| 15. Round | 21/08/2022 | Huracán | - | Newell's Old Boys | 1:0 | ||||
| 17. Round | 03/09/2022 | Vélez Sarsfield | - | Newell's Old Boys | 0:1 | ||||
| 18. Round | 11/09/2022 | Newell's Old Boys | - | Gimnasia de La Plata | 2:0 | ||||
| 19. Round | 14/09/2022 | Aldosivi | - | Newell's Old Boys | 1:2 | ||||
| 22. Round | 01/10/2022 | Unión de Santa Fe | - | Newell's Old Boys | 0:1 | ||||
| 24. Round | 11/10/2022 | Central Córdoba SdE | - | Newell's Old Boys | 0:3 | ||||
| 27. Round | 24/10/2022 | Barracas Central | - | Newell's Old Boys | 1:1 |
Argentina