| 1. Round | 19/07/2021 | Central Córdoba SdE | - | Banfield | 1:1 |  |
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| 2. Round | 24/07/2021 | San Lorenzo | - | Central Córdoba SdE | 1:0 | ||||
| 3. Round | 29/07/2021 | Central Córdoba SdE | - | Talleres de Córdoba | 2:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors | - | Central Córdoba SdE | 1:1 | ||||
| 5. Round | 10/08/2021 | Central Córdoba SdE | - | Estudiantes | 1:2 | |
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| 6. Round | 15/08/2021 | Patronato de Paraná | - | Central Córdoba SdE | 1:0 | |
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| 10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 | ||||
| 15. Round | 08/10/2021 | Central Córdoba SdE | - | Huracán | 1:2 | ||||
| 16. Round | 15/10/2021 | Godoy Cruz | - | Central Córdoba SdE | 0:0 | |
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| 17. Round | 20/10/2021 | Central Córdoba SdE | - | Vélez Sarsfield | 1:2 | ||||
| 23. Round | 30/11/2021 | Central Córdoba SdE | - | Arsenal de Sarandí | 5:0 |
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