| 7. Round | 21/08/2021 | Arsenal de Sarandí | - | Racing Club | 0:3 | ||||
| 8. Round | 25/08/2021 | Racing Club | - | Central Córdoba SdE | 0:0 | ||||
| 10. Round | 05/09/2021 | Racing Club | - | Banfield | 0:0 | ||||
| 13. Round | 27/09/2021 | Argentinos Juniors | - | Racing Club | 2:0 | ||||
| 14. Round | 04/10/2021 | Racing Club | - | Estudiantes | 1:1 | ||||
| 15. Round | 09/10/2021 | Patronato de Paraná | - | Racing Club | 1:2 |  |
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| 16. Round | 15/10/2021 | Racing Club | - | Platense | 0:1 | ||||
| 17. Round | 19/10/2021 | Unión de Santa Fe | - | Racing Club | 1:1 | ||||
| 18. Round | 24/10/2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 19. Round | 29/10/2021 | Racing Club | - | Defensa y Justicia | 1:2 | ||||
| 20. Round | 06/11/2021 | Atlético Tucumán | - | Racing Club | 0:2 | |
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| 21. Round | 21/11/2021 | Racing Club | - | Colón de Santa Fe | 1:2 | ||||
| 22. Round | 26/11/2021 | River Plate | - | Racing Club | 4:0 | ||||
| 23. Round | 29/11/2021 | Racing Club | - | Lanús | 3:1 | ||||
| 24. Round | 05/12/2021 | Huracán | - | Racing Club | 1:0 | ||||
| 25. Round | 11/12/2021 | Racing Club | - | Godoy Cruz | 2:1 |
Uruguay