| 1. Round | 17/07/2021 | Lanús | - | Atlético Tucumán | 4:2 |  |
|||
| 2. Round | 23/07/2021 | Atlético Tucumán | - | Huracán | 1:0 | ||||
| 3. Round | 28/07/2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 | |
|||
| 4. Round | 03/08/2021 | Atlético Tucumán | - | Vélez Sarsfield | 0:0 | ||||
| 5. Round | 08/08/2021 | Gimnasia de La Plata | - | Atlético Tucumán | 1:0 | ||||
| 6. Round | 14/08/2021 | Atlético Tucumán | - | Aldosivi | 2:2 | |
|||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 |  |
|||
| 9. Round | 30/08/2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | |
|||
| 10. Round | 04/09/2021 | Atlético Tucumán | - | Arsenal de Sarandí | 0:0 | |
|||
| 11. Round | 14/09/2021 | Central Córdoba SdE | - | Atlético Tucumán | 2:0 | ||||
| 12. Round | 19/09/2021 | Atlético Tucumán | - | Boca Juniors | 1:2 |  |
|||
| 15. Round | 12/10/2021 | Talleres de Córdoba | - | Atlético Tucumán | 2:0 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán | - | Argentinos Juniors | 4:3 | |
|||
| 19. Round | 30/10/2021 | Platense | - | Atlético Tucumán | 4:1 | |
|||
| 20. Round | 06/11/2021 | Atlético Tucumán | - | Racing Club | 0:2 | ||||
| 21. Round | 20/11/2021 | Rosario Central | - | Atlético Tucumán | 3:1 |
Argentina
Italy