| 1. Round | 29/07/2021 | Atlético Morelia | - | Mineros de Zacatecas | 2:2 | ||||
| 2. Round | 04/08/2021 | Dorados de Sinaloa | - | Atlético Morelia | 3:1 | ||||
| 3. Round | 10/08/2021 | Atlético Morelia | - | Club Celaya | 2:1 | ||||
| 4. Round | 19/08/2021 | Tapatío | - | Atlético Morelia | 0:3 | ||||
| 5. Round | 27/08/2021 | Atlético Morelia | - | Correcaminos UAT | 2:1 | ||||
| 7. Round | 12/09/2021 | Atlético Morelia | - | Cimarrones de Sonora | 2:2 |  |
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| 8. Round | 16/09/2021 | Venados FC | - | Atlético Morelia | 0:1 | |
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| 9. Round | 24/09/2021 | Atlético Morelia | - | Alebrijes de Oaxaca | 1:0 |  |
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| 10. Round | 01/10/2021 | Leones Negros | - | Atlético Morelia | 2:1 | |
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| 11. Round | 10/10/2021 | Atlético Morelia | - | Atlante | 1:0 | ||||
| 12. Round | 14/10/2021 | Cancún FC | - | Atlético Morelia | 0:1 | ||||
| 13. Round | 24/10/2021 | Atlético Morelia | - | Tepatitlán | 2:2 | ||||
| 14. Round | 29/10/2021 | Atlético Morelia | - | Pumas Tabasco | 0:1 | ||||
| 15. Round | 04/11/2021 | TM Fútbol Club | - | Atlético Morelia | 1:1 | ||||
| 16. Round | 09/11/2021 | Atlético Morelia | - | Coyotes de Tlaxcala | 1:3 | ||||
| 17. Round | 16/11/2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
Venezuela