| 6. Round | 18/03/2022 | San Telmo | - | Deportivo Riestra | 0:0 | ||||
| 7. Round | 24/03/2022 | Belgrano de Córdoba | - | San Telmo | 3:1 | ||||
| 8. Round | 27/03/2022 | San Telmo | - | Villa Dálmine | 0:4 | ||||
| 9. Round | 03/04/2022 | Almirante Brown | - | San Telmo | 1:1 | ||||
| 10. Round | 10/04/2022 | San Telmo | - | Gimnasia de Jujuy | 0:0 | ||||
| 11. Round | 16/04/2022 | Flandria | - | San Telmo | 3:3 |  |
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| 12. Round | 23/04/2022 | San Telmo | - | Temperley | 3:1 | ||||
| 13. Round | 30/04/2022 | Deportivo Morón | - | San Telmo | 3:1 | ||||
| 14. Round | 06/05/2022 | San Telmo | - | Deportivo Madryn | 2:1 | ||||
| 15. Round | 15/05/2022 | Estudiantes de Río Cuarto | - | San Telmo | 2:1 | ||||
| 16. Round | 22/05/2022 | San Telmo | - | Alvarado | 0:1 | ||||
| 17. Round | 30/05/2022 | Almagro | - | San Telmo | 2:1 | ||||
| 18. Round | 05/06/2022 | San Telmo | - | Nueva Chicago | 1:1 |
Argentina