| 1. Round | 18/07/2021 | Huracán | - | Defensa y Justicia | 2:1 |  |
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| 2. Round | 23/07/2021 | Atlético Tucumán | - | Huracán | 1:0 | ||||
| 3. Round | 27/07/2021 | Huracán | - | Colón de Santa Fe | 1:1 | ||||
| 7. Round | 21/08/2021 | Godoy Cruz | - | Huracán | 1:1 | ||||
| 8. Round | 25/08/2021 | Huracán | - | Vélez Sarsfield | 1:1 | ||||
| 9. Round | 28/08/2021 | Gimnasia de La Plata | - | Huracán | 0:0 | ||||
| 10. Round | 04/09/2021 | Huracán | - | Aldosivi | 2:0 | ||||
| 12. Round | 19/09/2021 | Huracán | - | Independiente | 0:1 | |
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| 17. Round | 20/10/2021 | Banfield | - | Huracán | 1:4 | |
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| 18. Round | 24/10/2021 | Huracán | - | San Lorenzo | 2:1 | ||||
| 19. Round | 30/10/2021 | Talleres de Córdoba | - | Huracán | 1:0 | ||||
| 20. Round | 08/11/2021 | Huracán | - | Argentinos Juniors | 1:1 | ||||
| 21. Round | 19/11/2021 | Estudiantes | - | Huracán | 4:1 | ||||
| 25. Round | 11/12/2021 | Rosario Central | - | Huracán | 1:4 |
Argentina
Italy