| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 |  |
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| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 |  |
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| 6. Round | 11/09/2021 | SC Toulon | - | AS Monaco B | 3:0 | ||||
| 7. Round | 18/09/2021 | AS Monaco B | - | FC Martigues | 2:0 | ||||
| 8. Round | 25/09/2021 | GFA Rumilly Vallières | - | AS Monaco B | 1:2 | ||||
| 9. Round | 09/10/2021 | AS Monaco B | - | AS Saint-Priest | 4:2 | ||||
| 10. Round | 23/10/2021 | Étoile FC | - | AS Monaco B | 1:1 | ||||
| 11. Round | 06/11/2021 | AS Monaco B | - | GOAL FC | 0:2 | ||||
| 12. Round | 20/11/2021 | Aubagne FC | - | AS Monaco B | 4:1 | ||||
| 13. Round | 04/12/2021 | AS Monaco B | - | Jura Sud | 1:1 | ||||
| 15. Round | 15/01/2022 | AS Monaco B | - | Marignane Gignac FC | 0:1 | ||||
| 16. Round | 22/01/2022 | RC Grasse | - | AS Monaco B | 0:0 | |
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| 17. Round | 05/02/2022 | AS Monaco B | - | Louhans-Cuiseaux | 1:1 | ||||
| 19. Round | 19/02/2022 | AS Monaco B | - | Lyon-La Duchère | 2:2 |  |
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| 20. Round | 05/03/2022 | AS Monaco B | - | SC Toulon | 0:1 | |
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| 21. Round | 12/03/2022 | FC Martigues | - | AS Monaco B | 1:2 | ||||
| 22. Round | 19/03/2022 | AS Monaco B | - | GFA Rumilly Vallières | 2:2 | |
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| 23. Round | 26/03/2022 | AS Saint-Priest | - | AS Monaco B | 2:1 |
France
Spain