| 4. Round | 02/08/2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 7. Round | 22/08/2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Round | 25/08/2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 |  |
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| 9. Round | 29/08/2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 10. Round | 05/09/2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Round | 15/09/2021 | Banfield | - | Rosario Central | 1:2 | ||||
| 12. Round | 20/09/2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 16. Round | 15/10/2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 17. Round | 19/10/2021 | Platense | - | Rosario Central | 1:1 | |
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| 18. Round | 24/10/2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 19. Round | 31/10/2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 | ||||
| 21. Round | 20/11/2021 | Rosario Central | - | Atlético Tucumán | 3:1 | ||||
| 22. Round | 25/11/2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | ||||
| 25. Round | 11/12/2021 | Rosario Central | - | Huracán | 1:4 |
Argentina
Italy