| 1. Round | 04/06/2022 | Godoy Cruz II | - | Platense II | 2:1 | ||||
| 2. Round | 08/06/2022 | Racing Club II | - | Godoy Cruz II | 1:0 | ||||
| 5. Round | 27/06/2022 | Godoy Cruz II | - | Atlético Tucumán II | 3:0 | ||||
| 6. Round | 02/07/2022 | Colón de Santa Fe II | - | Godoy Cruz II | 1:1 | ||||
| 7. Round | 09/07/2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 8. Round | 15/07/2022 | Lanús II | - | Godoy Cruz II | 2:3 |  |
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| 9. Round | 20/07/2022 | Godoy Cruz II | - | Huracán II | 1:3 | ||||
| 10. Round | 25/07/2022 | Godoy Cruz II | - | Unión de Santa Fe II | 1:1 | ||||
| 11. Round | 30/07/2022 | Vélez Sarsfield II | - | Godoy Cruz II | 5:0 | ||||
| 16. Round | 26/08/2022 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 18. Round | 07/09/2022 | Godoy Cruz II | - | Central Córdoba SdE II | 5:1 | ||||
| 19. Round | 13/09/2022 | Tigre II | - | Godoy Cruz II | 2:0 | ||||
| 24. Round | 07/10/2022 | Godoy Cruz II | - | Talleres de Córdoba II | 2:4 |  |
Argentina