| 1. Round | 07/08/2021 | Olympique Lyonnais B | - | AS Monaco B | 1:0 | ||||
| 3. Round | 21/08/2021 | Olympique Lyonnais B | - | GFA Rumilly Vallières | 0:2 | ||||
| 4. Round | 28/08/2021 | AS Saint-Priest | - | Olympique Lyonnais B | 1:3 | ||||
| 5. Round | 04/09/2021 | Olympique Lyonnais B | - | Étoile FC | 3:0 | ||||
| 6. Round | 11/09/2021 | GOAL FC | - | Olympique Lyonnais B | 2:0 | ||||
| 7. Round | 18/09/2021 | Olympique Lyonnais B | - | Aubagne FC | 3:1 |  |
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| 8. Round | 25/09/2021 | Jura Sud | - | Olympique Lyonnais B | 1:1 | ||||
| 10. Round | 23/10/2021 | Marignane Gignac FC | - | Olympique Lyonnais B | 4:0 | ||||
| 13. Round | 18/12/2021 | Louhans-Cuiseaux | - | Olympique Lyonnais B | 1:2 | ||||
| 16. Round | 22/01/2022 | Olympique Lyonnais B | - | FC Martigues | 0:1 | ||||
| 17. Round | 05/02/2022 | GFA Rumilly Vallières | - | Olympique Lyonnais B | 0:0 | ||||
| 18. Round | 12/02/2022 | Olympique Lyonnais B | - | AS Saint-Priest | 0:0 | ||||
| 20. Round | 05/03/2022 | Olympique Lyonnais B | - | GOAL FC | 0:2 | ||||
| 22. Round | 19/03/2022 | Olympique Lyonnais B | - | Jura Sud | 0:4 | ||||
| 23. Round | 26/03/2022 | Olympique Marseille B | - | Olympique Lyonnais B | 0:2 | ||||
| 24. Round | 09/04/2022 | Olympique Lyonnais B | - | Marignane Gignac FC | 3:1 |
France
Morocco