| 3. Round | 14/06/2022 | San Lorenzo | - | Arsenal de Sarandí | 3:3 |  |
|||
| 4. Round | 22/06/2022 | Central Córdoba SdE | - | San Lorenzo | 0:2 | ||||
| 5. Round | 26/06/2022 | San Lorenzo | - | Tigre | 1:1 | ||||
| 7. Round | 09/07/2022 | San Lorenzo | - | Boca Juniors | 2:1 | ||||
| 8. Round | 17/07/2022 | Banfield | - | San Lorenzo | 1:1 | ||||
| 9. Round | 20/07/2022 | San Lorenzo | - | Unión de Santa Fe | 2:2 | ||||
| 13. Round | 13/08/2022 | Patronato de Paraná | - | San Lorenzo | 3:2 | ||||
| 17. Round | 05/09/2022 | Defensa y Justicia | - | San Lorenzo | 0:0 | ||||
| 18. Round | 10/09/2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 19. Round | 14/09/2022 | Colón de Santa Fe | - | San Lorenzo | 0:0 | ||||
| 20. Round | 18/09/2022 | San Lorenzo | - | River Plate | 0:1 | ||||
| 21. Round | 24/09/2022 | Lanús | - | San Lorenzo | 2:0 | ||||
| 22. Round | 01/10/2022 | San Lorenzo | - | Huracán | 1:0 | ||||
| 23. Round | 04/10/2022 | Godoy Cruz | - | San Lorenzo | 0:0 | ||||
| 24. Round | 08/10/2022 | San Lorenzo | - | Vélez Sarsfield | 1:0 | ||||
| 25. Round | 12/10/2022 | Gimnasia de La Plata | - | San Lorenzo | 0:1 | |
|||
| 26. Round | 18/10/2022 | Sarmiento de Junín | - | San Lorenzo | 2:4 |  |
|||
| 27. Round | 22/10/2022 | San Lorenzo | - | Aldosivi | 3:0 | |
Argentina