| 1. Round | 29/09/2005 | Anorthosis Famagusta | - | US Palermo | 0:4 | ||||
| Group B | 20/10/2005 | Maccabi Petach-Tikva | - | US Palermo | 1:2 | ||||
| Group B | 03/11/2005 | US Palermo | - | Lokomotiv Moskva | 0:0 | ||||
| Group B | 24/11/2005 | Espanyol Barcelona | - | US Palermo | 1:1 |  |
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| Group B | 15/12/2005 | US Palermo | - | Brøndby IF | 3:0 | ||||
| 3. Round | 16/02/2006 | Slavia Praha | - | US Palermo | 2:1 | ||||
| 3. Round | 23/02/2006 | US Palermo | - | Slavia Praha | 1:0 | ||||
| Round of 16 | 09/03/2006 | US Palermo | - | FC Schalke 04 | 1:0 | ||||
| Round of 16 | 16/03/2006 | FC Schalke 04 | - | US Palermo | 3:0 |  |
Argentina