| 4. Round | 08/08/2021 | Atlético San Luis [Women] | - | CF Pachuca [Women] | 1:1 | ||||
| 5. Round | 17/08/2021 | UANL Tigres [Women] | - | Atlético San Luis [Women] | 5:1 | ||||
| 8. Round | 04/09/2021 | Cruz Azul [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 9. Round | 12/09/2021 | Atlético San Luis [Women] | - | Atlas Guadalajara [Women] | 0:0 | ||||
| 10. Round | 24/09/2021 | Gallos Blancos [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 11. Round | 03/10/2021 | Atlético San Luis [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 12. Round | 10/10/2021 | Atlético San Luis [Women] | - | FC Juárez [Women] | 4:0 | ||||
| 13. Round | 17/10/2021 | Puebla FC [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 15. Round | 07/11/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 16. Round | 13/11/2021 | Club León [Women] | - | Atlético San Luis [Women] | 0:0 |  |
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| 17. Round | 21/11/2021 | Atlético San Luis [Women] | - | Club Necaxa [Women] | 1:1 |
Spain