| 1. Round | 08/01/2021 | Club Necaxa [Women] | - | Cruz Azul [Women] | 0:2 | ||||
| 2. Round | 14/01/2021 | Cruz Azul [Women] | - | Club León [Women] | 1:1 | ||||
| 3. Round | 22/01/2021 | Cruz Azul [Women] | - | Atlético San Luis [Women] | 3:1 | ||||
| 4. Round | 31/01/2021 | Puebla FC [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 5. Round | 05/02/2021 | CF Monterrey [Women] | - | Cruz Azul [Women] | 5:1 | ||||
| 6. Round | 08/02/2021 | Cruz Azul [Women] | - | Pumas UNAM [Women] | 0:2 | ||||
| 7. Round | 15/02/2021 | Deportivo Toluca [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 8. Round | 26/02/2021 | Cruz Azul [Women] | - | Club Tijuana [Women] | 0:0 | ||||
| 9. Round | 06/03/2021 | Atlas Guadalajara [Women] | - | Cruz Azul [Women] | 0:1 |  |
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| 13. Round | 29/03/2021 | Santos Laguna [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 15. Round | 16/04/2021 | Cruz Azul [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 16. Round | 25/04/2021 | CF América [Women] | - | Cruz Azul [Women] | 2:1 | ||||
| 17. Round | 30/04/2021 | Cruz Azul [Women] | - | Gallos Blancos [Women] | 2:5 |
Mexico