| 6. Round | 19/02/2022 | FC Juárez | - | Santos Laguna | 0:0 | ||||
| 7. Round | 26/02/2022 | FC Juárez | - | UANL Tigres | 2:3 | ||||
| 9. Round | 05/03/2022 | FC Juárez | - | Club León | 0:1 | ||||
| 11. Round | 21/03/2022 | Club Tijuana | - | FC Juárez | 1:0 | ||||
| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 |
Mexico